Formulation and evaluation of floating drug delivery system containing theophylline as a model drug

Abstract

The objective of this research work was to formulate and evaluate the floating drug delivery system containing theophylline as a model and to optimize the drug release profile. Theophylline tablets were prepared by direct compression. Formulations contain HPMC K100M, xanthan gum, carbopol 934P, PVP K30, MCC, lactose, aerosil and gas generating agent such as sodium bicarbonate were taken as independent variables. The effect of formulation variables on floating and drug release was evaluated. The release mechanisms of theophylline from floating tablet where evaluated on the basis of Peppas model.