Formulation and characterization of fast disintegrating tablets containing Cefdinir solid dispersion

Abstract

The study was carried out with a view to enhance dissolution rate of poorly water-soluble drug by preparing fast disintegrating tablets of solid dispersion of cefdinir, a third generation cephalosporin. Solid dispersion was prepared by using PVP K- 30 and additionally SLS was added as adjuvant which may increase the dissolution rate. Solid dispersion (SD) was prepared by solvent evaporation method using different ratios of cefdinir, polymer and SLS.  Optimized SD was incorporated into fast disintegrating tablets (FDT) for a faster release of cefdinir. In vitro dissolution rate of cefdinir from solid dispersion (SD) was significantly higher compared to pure cefdinir. DSC analysis indicated that crystallinity of SD has reduced significantly. FTIR analysis of SD showed no interaction between cefdinir, PVP K-30 and SLS. The dissolution rate of drug was affected by amount of polymer used. The dissolution rate of cefdinir solid dispersion prepared by taking molar ratio of drug: polymer 1:5 and 10% SLS was higher than that of cefdinir solid dispersion prepared by taking molar ratio of drug: polymer 1:6 and 10% SLS.  Thus, solid dispersion technique can be successfully used for the improvement of the dissolution profile of cefdinir. FS5 (cefdinir, PVP K-30, SLS) was incorporated into FDTs containing diluents (Microcrystalline cellulose, Lactose) and super-disintegrant (Crospovidone or sodium starch glycolate). FDTs were prepared by direct compression method. Disintegration time, were decreased in the formulations containing Microcrystalline cellulose and Crospovidone, but increased with Lactose and sodium starch glycolate, respectively (36±1.26 to 108±2.89 Sec). The FDT4 batch with disintegration time 36 ± 1.26 Sec was selected as optimized formulation.