In situ gel as a novel approach of gastroretentive drug delivery

Abstract

Among oral dosage form, liquid dosage forms are more prone to low bioavailability because of their quick transit from the stomach/ duodenum. To produce sustained release formulation of an oral liquid formulation could be successfully augmented substantially through a strategy of liquid in-situ gelling system. The formation of gels depends on factors like temperature modulation, pH change, presence of ions and ultra violet irradiation, from which the drug gets released in a sustained and controlled manner. The in situ gel forming polymeric formulations offer several advantages like sustained and prolonged action in comparison to conventional drug delivery systems and increase bioavailability of drug as well as produce patient compliance by reducing dosing frequency.