Development and Characterization of In-Situ Gel Forming Ophthalmic Formulation of Carteolol

Abstract

Eye is the most vital organ of body. The usual ophthalmic dosage forms are account for 90% of currently accessible ophthalmic formulations. Themajor trouble encountered is quick precornel drug loss. To improve ophthalmic drug bioavailability, there are considerable efforts directed towards newer drug delivery systems for ophthalmic administration. Newer research in ophthalmic drug delivery systems is directed towards an amalgamation of several drug delivery technologies, that includes to buid up systems whichis not only extend the contact time of the vehicle at theocular surface, butwhich at the same time slow down the removal of the drug. Conventional delivery systems often result in poor bioavailability and therapeutic response because high tear fluids turn over and dynamics causerapidelimination of the drug from the eyes. So, to overcome bioavailability problems, ophthalmic in situ gels were developed.