Anti-inflammatory and analgesic activity of methanol extract of bark of Acacia suma (Roxb.)

Abstract

The methanol extract of Acacia suma (Roxb.) barks (Family-Fabaceae) showed significant anti-inflammatory and analgesic activity. The acute toxicity, orally evaluated in mice, was found to be higher than 2000 mg/kg. The anti-inflammatory activity using carrageenan was examined. The antinociceptive response using writhing and tail immersion test in mice were also examined. The percentage inhibition of oedema due to injection of carrageenan was found to be in accordance with the doses tested. The extract at the doses 200 and 400 mg/kg significantly reduced the numbers of writhings induced by intraperitoneal injection of acetic acid in mice. But the extract significantly exerted protective effects on heat-induced pain in mice at all tested doses (100, 200 and 400 mg/kg p.o.).The presence of flavonoids in the methanol extract may be contributory to its anti-inflammatory and analgesic activity.