Evaluation of Anti-inflammatory activity of Hydro-alcoholic extract Diplocyclos palmatus (L.) Jeffry. roots in experimental animals

Abstract

Diplocyclos palmatus (l.) Jeffry. commony known as Shivlingi belongs to family Cucurbitaceae had been widely used for its reported biological activities in indigenous system of medicine. The present investigation was carried out to find the effect of hydro-alcoholic extract of roots of Diplocyclos palmatus (l.) Jeffry. for its anti-inflammatory activity. The anti-inflammatory activity was evaluated using acute inflammatory models viz., carrageenan induced paw oedema. Oral administration of the extract at the doses 100 and 200 mg/kg b.w. exhibited dose dependent and significant anti-inflammatory activity in (p < 0.01). Hence, present investigation established pharmacological evidences to support the folklore claim that Diplocyclos palmatus (l.) Jeffry. is used as anti-inflammatory agent.