Antibacterial activity of Flacourtia jangomas and Flacourtia sepiaria

Abstract

The chloroform soluble fraction of Flacourtia jangomas and Flacourtia sepiaria were subjected to in vitro antibacterial screening (by disc diffusion method) against two Gram positive and two Gram negative bacteria to know antimicrobial effectiveness. Chloroform fraction of Flacourtia jangomas showed good activity against all the tested bacteria and among them E. coli was found the most susceptible bacterium with the zone of inhibition was 14 ± 0.59 mm. Flacourtia sepiaria had no activity against E. coli and Bacillus cereus. In respect of the zone of inhibition of both plant fractions, Flacourtia jangomas was better activity than Flacourtia sepiaria.  Among all tested extract, only F. jangomas extract showed significant MIC value, ranges of (0.325 to 5 mg/ml). In toxicity study, the chloroform fraction of Flacourtia jangomas showed toxic effect using brine shrimp lethality bioassay with LC₅₀ values of 12.58 mg/ml.