Evaluation of anticonvulsant activity of Mesua ferrea Linn. ethanolic flower extract

Abstract

To study the anticonvulsant activity of ethanolic extract of Mesua ferrea in albino mice. Anticonvulsant activity for Mesua ferrea was evaluated in albino mice of either sex at 3 different dose levels (200, 400 and 600 mg/kg p.o.) by MES assessed using albino mice against Maximum Electroshock Seizure (MES) test. The ethanolic extract of Mesua ferrea reduced the duration of hind limb tonic extension (HLTE) in a dose dependent manner against MES model. The ethanolic extract of Mesua ferrea inhibits MES-induced convulsions. The extract showed significant (p<0.001) against both MES (maximal electroshock).