Antihyperglycaemic activity on flower of Polygonum orientale Linn. using steptozotocin induced diabetic mice model

Abstract

The anti hyperglycaemic effect of aqueous extract of the flower of Polygonum orientale Linn. in streptozotocin (STZ) induced diabetic mice was investigated. The flower extract of in doses 100 and 200 mg/kg b.w was administered for 21 days and blood glucose level, serum cholesterol, liver glycogen was estimated. Treatment of the Streptozotocin induced diabetic mice with the flower extract resulted in significant reduction of blood glucose level (P<.0001), serum cholesterol (P<.01) and increase in liver glycogen (P<.0001). The results suggest that the flower extract of Polygonum orientale Linn .possess anti hyperglycaemic effect in Streptozotocin induced diabetic mice which justify the traditional use of this plant as ethnomedicine in treatment of diabetes.