Female ovarian hormone- Estriol's proconvulsant effect with kainic acid in Drosophila system model

Abstract

The effect of estriol would be evaluated for its effect on Drosophila fly model. Seizures in drosophila and man have
several similarities and the utility of the fruit fly as a genetic model system for studying human seizures disorder and
seizure susceptibility has clearly been demonstrated (Glasscock et al., 2005). Drosophila fly of 3-4 days old unmated
fly were used. Drosophila model, optimized for screening of drugs dissolved in DMSO was used. Thirty flies were
housed in each treatment vial. Three to four days old unmated male flies was treated with 8 mg/ml KA containing
media for required time duration. A regimen for drosophila fly model where it was treated with kainic acid and
resulted in increases as well as decrease of climbing speed for adult Drosophila fly. As higher organism has more
colossal complexity thats why drosophila fly model is favored. This model is convenient to use and it is very
relevant too.