Spectrophotometric method for estimation of cefpodoxime proxetil and ofloxacin in tablet dosage form by simultaneous equation method

Abstract

A simple, rapid, accurate and precise spectrophotometric method has been developed for simultaneous estimation of cefpodoxime proxetil and ofloxacin from tablet dosage form. Proposed method involves formation of ‘simultaneous equations’ at 235 nm and 298 nm, using methanol: water (70:30), as a solvent. The linearity was observed in the concentration range of 4 - 24 µg/ml for cefpodoxime proxetil and 4 - 20 µg/ml for ofloxacin. The results of analysis have been validated statistically and by recovery studies.