Modelling of Ca inhibitory activity of sulfonamides

Abstract

In the present investigation the applicability of various physicochemical parameters are tested for the QSAR study on sulfonamides. For the modeling of Inhibitory activities of sulfonamides the regression analysis shows that even in the multi parametric correlation of physicochemical parameters give significant regression coefficients. Furthermore using combinations of physicochemical parameters along with the indicator parameters, a tremendous improvement in the statistics has been observed. The results are critically discussed on the basis of regression data.