QSAR Study of α, β unsaturated ketone as potent antifungal agents

Abstract

To explore physicochemical properties of α, β Unsaturated Ketone derivative for their anti-fungal activity, a quantitative structure activity relationship, Hansch approach was applied on twenty compounds of above mentioned derivative . Various physicochemical and topological descriptor and reported minimum inhibitory concentration value of C. albicans were used as independent variables and dependent variable respectively. It was revealed that mixed descriptor were found to have overall significant correlation ship with antifungal activity and these studies provide an insight to design new molecule