Solid dispersion formulations of Pioglitazone HCl using five different polymers for enhancing dissolution profile

Abstract

Many drugs are abandoned due to poor aqueous solubility, although having a potential therapeutic effect. Numerous methods have been followed to improve the dissolution rate of poorly water soluble drugs. Solid dispersion is successfully applied to improve the solubility and consequently the bioavailability of poorly water soluble drugs. The aim of present study was to prepare solid dispersions of Pioglitazone HCl with PEG 6000, PVP, Poloxamer 407, Eudragit EPO and HPMC and determine the effect of those polymers on dissolution of pioglitazone HCl. solid dispersion of Pioglitazone HCl was prepared by solvent evaporation method. Solid dispersions were evaluated with respect to their yield percentage, percent drug content, FT-IR spectra and in vitro dissolution studies. The histogram response, descriptive statistics of response ensure the fitness of the experiment. The result obtained show that the dissolution profile of Pioglitazone HCl solid dispersion was considerably improved. Solid dispersions of Pioglitazone HCl with PVP K30, HPMC, PEG 6000, Eudragit EPO and Poloxamer 407 shows 75%, 74%, 100%, 50% and 62%  release respectively after 30 minutes where as Pioglitazone HCl shows only 12.05%. Based on the result solid dispersion technique can be an acceptable method for improving the dissolution profile of poorly aqueous soluble drug.