Enhancement of bioavailablity of rifapentine by solid dispersion technique

Abstract

This work describes a solid dispersion technique to improve the solubility and dissolution characteristics of a poorly water-soluble drug, rifapentine. The solid dispersion with polyethylene glycol (PEG) 4000 and Mannitol have been prepared by different methods in different ratios and found that solvent evaporation (CS₄) shows the better enhancement of solubility in comparison to the kneading and physical mixture method.