Lipid Based Drug Delivery System for enhancing oral absorption of Biopharmaceuticals

Abstract

Low bioavailability and therapeutic efficacy are the results of poorly aqueous soluble medicines' inadequate combination of drug absorption, water solubility, and dissolution. Low bioavailability further reduces the administered method's effectiveness and efficiency. Therefore, a medication delivery system that can guarantee therapeutic efficacy and adequate drug bioavailability must be developed. Class II and IV medication molecules, according to the biopharmaceutical categorization system, have very poor oral bioavailability due to their inappropriate solubility in gastrointestinal fluids.Most pharmacological compounds, notably BCS class II, have a limited dissolving rate, affecting absorption.   Most conventional drug delivery systems fail to achieve desired dissolution rates and maintain the drug in a solubilized state at the absorption site, resulting in poor drug bioavailability and therapeutic efficacy.   Pre-dissolved drugs are used in this method to get around limitations on dissolving rate and increase lymphatic system absorption, which makes the medication bioavailability and therapeutic efficacy better.