Synthesis and Characterization of 1,2-Dihydroquinoline Sulphonamides: Novel Derivatives with Enhanced Pharmacological Potential

Abstract

The present investigation reports the synthesis and characterization of a novel series of 1,2-dihydroquinoline sulphonamides, developed with the aim of enhancing their pharmacological efficacy. The synthesis involved a multi-step process starting with the preparation of 3-hydroxy Acetanilide, followed by Pechmann condensation to obtain acetylated aminophenol, and subsequent reactions leading to the formation of 1,2- dihydroquinoline derivatives. These derivatives were further reacted with various substituted sulphonyl chlorides to yield the target sulphonamide compounds. The synthesized compounds were characterized using FT- IR, 1H NMR, 13C NMR, and LCMS. Their pharmacological activities, including antibacterial, anthelmintic, anti-inflammatory, and antihyperlipidemic properties, were evaluated through in-vitro assays. The results demonstrated that these novel 1,2-dihydroquinoline sulphonamides exhibit promising pharmacological activities, validating their potential as effective therapeutic agents.