Association of PPARG2 pro12ala polymorphism with osteoarthritis in Central India

Abstract

The aim of this study was to investigate the possible association between the Pro12Ala polymorphism of the PPARγ
gene with osteoarthritis in vindhya region population.We performed PCR-restriction fragment length polymorphism
to determine the Pro12Ala polymorphism in 140 patients with osteoarthritis and 160 normal control subjects.
Distribution pattern of genotypes and allele frequency suggests no significant difference among case and control
group. PPARG2 polymorphism is not associated with risk of osteoarthritis in this region.