Association study of SLC11A1 gene (3’UTR) gene polymorphism with pediatric tuberculosis in Madhya Pradesh, India

Abstract

Natural resistance associated macrophage protein 1 (NRAMP1) encoded by the SLC11A1 quality, has been depicted
to manage macrophage initiation and be related with irresistible and immune system ailments. The connection
between SLC11A1 polymorphisms and tuberculosis vulnerability has been considered in various populaces. these
are no relationship between NRAMP1 polymorphism with the affinity for improvement of pneumonic tuberculosis
or tuberculous spondylitis. Truth be told, NRAMP1 may give insurance against the improvement of tuberculous
spondylitis. The human homologue of the NRAMP1, assigned NRAMP1, has been cloned and mapped to
chromosome 2q35. In ongoing occasions, number of qualities has been explored in different case control thinks
about, of which the regular resistance– related macrophage protein (NRAMP1) is believed to be imperative in the
intracellular slaughtering of Mycobacteria.
In our populace, (NRAMP1) isn't related with pediatric tuberculosis. TGTG +/+ genotype did not demonstrate any
critical changes in conveyance among solid control subjects and TB patients despite the fact that the TGTG+
genotype was higher in control bunch than TB patients (61.25 % versus 57.46% individually). The genotype TGTG-
(TGTG erasure) was measurably non critical (χ2 =0.6637, P=0.4153) in this populace and this genotype was
discovered lesser in the two patients and sound control subject gatherings (8.21% and 6.25% respectively).The
heterozygous TGTG +/ - genotype dispersion was marginally extraordinary in TB patients and control gathering
(34.33% versus 32.5% separately). The TGTG + allele was higher in control gathering (77.5% ) than patients
(74.63%) while TGTG-allele was lower in charge gathering (22.5 %) contrasted with TB patients (25.37%) however
the distinctions are factually non huge (χ2 =0.6637, P= 0.4153). The carriage rate of TGTG+ allele was practically
same in patients and control while the TGTG-allele carriage rate was higher in patients (42.53% versus 38.75%) yet
the chances proportion of TGTG-allele is 1.121 and TGTG-allele carriage rate is 0.8919.