A Review on Topical Film Forming Spray

Abstract

Some disadvantages of conventional medication formulations for topical
application include low permeability, poor adhesion to skin, and reduced
patient compliance. These new drug delivery methods intended for
topical administration are called topical film forming systems. the skin,
which clings to the body to create a thin, translucent layer that allows
active ingredients to be delivered to bodily tissue over an extended

period of time. The current study's goal was to develop and assess spray-
based film-forming techniques for bacterial and fungal diseases. Film-
forming polymers were added to the solvent system to make the

formulation, and then the plasticizer and medication were added.
Clotrimazole combined with ethyl cellulose and Eudragit RS 100 as film
formers, PEG 400 and PEG 5000 as plasticizer, to create two distinct
film-forming spray solutions using acetone and ethanol as the solvent
combination. Using Design Expert 13 software, 32 factorial design was
used for optimisation.

A number of factors, including viscosity, drying time, spray angle, film formation time, drug release,

antimicrobial activity, pH, and water washability, were assessed for the optimised formulations.Film-
forming methods offer advantages such as controlled release, lower dosage, water resistance, preventing

secondary infections, and decreased wiping risk, which will make them an excellent platform for topical
treatment against a variety of skin illnesses. in contrast to the traditional semisolid dosage forms, such as
contact-free application, peel-out, etc.