Effect of madhumeh an antibiotic polyherbal formulation on carbohydrate metabolism and antioxidant defence in Streptozotocin-Nicotinamide (STZ-NICO) induced diabetic rats

Abstract

The present investigation was undertaken to validating the antidiabetic claim of the polyherbal formulation madhumeh and to investigate the antioxidant activity in streptozotocin– nicotinamide induced diabetic rat model. Evaluation of Antidiabetic activity of polyherbal formulation in Streptozotocin – Nicotinamide induced diabetic rats and Induction of diabetes in animal and estimation of biochemical parameters. Madhumeh possesses blood glucose lowering comparable to standard oral hypoglycemic agent glibenclamide. Madhumeh showed marked increase in total protein in diabetic treated and lower the level of triglyceride in serum. Body weight, food intake, water intake are improved in formulation treated rats compared to diabetic rats suggesting the returning of glucose uptake utilization back to normal levels. Ours study shows that the hepatic antioxidant enzyme (SOD, CAT and GSH) levels were increased significantly with a significant reduction of LPO on treatment. Madhumeh exhibited good free radical scavenging property.