Formulation Development and Evaluation of Triamcinolone Ointment

Abstract

This Study was carried out with an aim of formulation development and in vitro evaluation of triamcinolone ointment 0.5%. An attempt was made to formulate a bioequivalent ointment dosage form of anti-inflammatory agent and anti-pruritics with in vitro release profile matching the standard specification. Based on literature information, pre-formulation studies and also result of first batch the manufacturing process in point no (7.2.2.1) was decided to adopt. Results of the present study advocate that Experiment for triamcinolone Ointment was selectedbased on 2 month stability studies at 25°C/60%, 30°C/65% and 40°C/75% conditions. The good degree of in vitro release study established the triamcinolone drug availability. Although remarkable achievements in topical corticosteroid therapy have been attained since this diseases was first recognized more than a decade ago, enormous challenges remain for the researchers to ultimately curb the progression and find a cure for Topical inflammations.