In-Vitro Disintegration Studies of different Parameters of Meloxicam

Abstract

Compressed parameters were tested for the physical parameters such as hardness, thickness, stability, weight weight evaluated for drug content, in-vitro release profile. Average. The weight difference of the tablet was predicted by direct compression that all the tablets showed the same weight with lower standard deviation values within acceptable variation as shown in the table. The in-vitro disintegration study was done using the USP type II tablet disruption tester using basket type at 50 rpm for all types, using 900 ml of 0.1N HCL and 6.8 phosphate buffer dissolution medium. Samples withdrawn using the UV spectrophotometer were analyzed. In direct compression, the F1 shows good response due to the presence of superdisoning. It can be concluded that the sample given by the Meloxicam was authentic and the result of this study, in accordance with the official monographs and standards given in the literature. Various data ready to prepare spectroscopy and standard curve was reproducible and can be used for further formulation study in formulation studies.