Phytochemial investigation and evaluation of antiemetic & anthelmintic activities of Polygonum lapathifolium roots extract

Abstract

The present study was designed to explore the phytochemical constituents, anti-emetic & anthelmintic effect of methanolic extract of Polygonum lapathifolium roots. The phytochemical screening shows the presence of alkaloids, phytosterols, triterpins, flavonoids. & Saponin, those are responsible for antiviral, antibacterial, antiallergic, antihypertensive, antiarrythmic, hepatoprotective, anti-inflammatory effects in mammals. In vitro anthelmintic activity test (using Pheretima posthuma model), the parameters like: time of paralysis and time of death were determined by using the extracts at the concentrations of 20, 40, 60, 80 and 100 mg/ml. The roots extracts exhibited significant anthelmintic activity at a concentration of 60mg/ml. Observations were comparable with piperazine citrate (10mg/ml) as standard reference. In anti-emetic test, emesis was induced by the oral administration of copper sulphate (50mg/kg) using chick emesis model. Roots extract (150mg/kg orally) showed statistically significant antiemetic effect (89.37% Inhibition) compared with reference drug metoclopramide (50mg/kg intraperitoneally) which showed 82.48% antiemetic activity.