Formulation and Evaluation of Fast Dissolving film of Granisetron Hydrochloride

Abstract

The objective of present research work was to develop Fast Dissolving film of Granisetron Hydrochloride for treatment of emesis and to increase dissolution profile to get fast onset of action.In this present study various concentration of HPMC K-15 and Pullulan were selected on the basis of extensive literature survey. Various concentration of both film forming agents were prepared in ten batches as MOF-I to MOF-X. The optimization of film forming agents was done on basis of general appearance, thickness and weight. The optimized oral film shows good tensile strength, percentage elongation and folding endurance. The dissolution data revealed that all drugs release within 30 min and release were constant after 40 min which shows the fast release of the drug from films.On comparing the dissolution data of optimized batch with marketed Tablet Grandem- 2mg (aristo pharmaceuticals). It was found that optimized film shows better on set of action and may show better bioavailability than tablet. Hence film can be used as alternative dosage form for treatment of emesis.