RP-HPLC method for the simultaneous determination of metoclopramide hydrochloride and paracetamol in tablet dosage form

Abstract

A simple precise and rapid reversed phase High Performance Liquid Chromatography method was developed for simultaneous determination of metoclopramide hydrochloride and paracetamol from pharmaceutical dosage form. The method was carried out on a HiQsil C8, (4.6×250mm) column with a mobile phase consisting of acetonitrile: acetate buffer (pH 6.78) (50:50v/v) at a flow rate of 1ml/min. Detection was carried out at 308 nm. The retention time of paracetamol and metoclopramide hydrochloride was 3.2 and 5.5 min respectively. The developed method was found to be accurate, precise and selective for simultaneous determination of Metoclopramide hydrochloride and paracetamol in tablets.