Solubility enhancement of ibuprofen using hydrotropic agents

Abstract

Ibuprofen, a weakly acidic, non-steroidal anti inflammatory drug having high permeability through stomach but due to its solubility limitation it can’t enter in to systemic circulation and gastric empting time ranging from 30 min to 2 hr, after this time ibuprofen goes in to small intestine where it is solubilise but can’t permeate through its membrane. The same problem arises in quantitative analysis; because of poor solubility of ibuprofen it involves organic solvents which are costly and toxic. To improve dissolution of such drug is challenging and rational. The purpose of the present study was to examine the enhancement of solubility of the Ibuprofen on addition of hydrotropic substances. Solubility of ibuprofen was determined with various surfactants and of various concentrations using phase solubility analysis. Since solubilization of non-polar drugs constitutes one of the most important tasks in formulation design, quantitative analysis and dissolution study.