Synthesis and Antioxidant Activity of Targeted Hybrid Compounds of Imidazopyridine linked with Thiazolidinone, Methyl thiazolidinone, and Triazolothiadiazole

Abstract

The current research focuses on the synthesis of hybrid compounds derived from imidazopyridine and fused heterocyclic ring systems, such as thiazolidinone, methyl thiazolidinone, and triazolothiadiazole. These compounds were evaluated for their antioxidant activities using the DPPH free radical scavenging assay. The synthesized compounds exhibited varying degrees of activity, with several compounds, including 6h and 9g, showing antioxidant activity comparable to the standard L-ascorbic acid. The EC50 values for these compounds were determined and their dose-dependent inhibition patterns were analyzed. These findings suggest that the presence of a hydroxyl group in the phenyl ring plays a significant role in enhancing antioxidant potential. This study contributes to the development of novel antioxidant agents with potential therapeutic applications in oxidative stress-related diseases.