Association of Aldosteron Synthase CYP11B2 C-344T) Gene Polymorphism Susceptibility to Essential Hypertension in a Central India Population

Abstract

The aldosteron synthase gene (CYP11B2) is an important candidate gene region in essential hypertension it is the key enzyme in the biosynthesis of aldosteron. We therefore studied the association of -344 T/C polymorphism of the CYP11B2 gene with the presence and severity of hypertension in Case-Control study. We studied 440 individuals, of whome 210 were hypertensive patients and 230 controlled hypertensive individuals.

In this study χ2 and p value of overall genotype frequency was CC, CT and TT =3.560, (0.1687), Df-2 and the allele frequency was C and T=0.02810, (0.8669), Df-1 and Carriage Rate was C and T=0.001915, (0.9651), Df-1 for the total central Indian population in this study there was no significant variance in blood pressure among any of the three genotype.