Antiulcer activity of Bridelia retusa by Pyloric ligation method on rats

Abstract

The present study is carried out in order to evaluate the antiulcer activity by using the methanolic leaf extract of Bridelia retusa in pyloric ligation induced model of rats and to compare its activity with that of ranitidine. Antiulcer activity was examined by pyloric ligation on male Albino wistar rats. Ranitidine was used as the standard drug for comparision. Bridelia retusa was administered in two doses, low dose (200 mg/kg) and high dose (400 mg/kg) and the treatments were given by oral route for seven consecutive days. The antiulcer effect of both the doses was compared with that of ranitidine in terms of volume of gastric content, pH, acidity and ulcer index. The resuts emphasize that the extract showed significant decrease in the gastric volume and acidity and increase in pH when compared to the control in pyloric ligated ulcer model. This study suggests that Bridelia retusa possess antiulcer properties and its use in the treatment of gastric ulcer.