Effect of various polymers on swelling and in vitro release of ramipril in effervescent system

Abstract

Tablet can be Utilized for precise delivery of drugs and reduce the drug concentrations at sites other than the target organ.  The  present  study  performed  by preparation  and  evaluation  of  floating  tablets  of Ramipril as model drug. For prolongation of gastric residence time floating effervescent tablets were formulated by various materials like. hydroxypropyl methylcellulose (HPMC) K 4M, K 15M, K 100M and micro crystalline cellulose and gas generating agent like sodium bicarbonate and evaluated for floating properties, swelling characteristics and drug release studies. In vitro drug release studies were performed and drug release kinetics evaluated using the linear regression method was  found  to  follow  both  the  Higuchi  and  the  Korsemeyer Peppas  equation. The drug release mechanism was found non-fickian type in most of the formulations.  The developed floating tablets of Ramipril may be used in clinic for prolonged drug release for at least 12 h, thereby improving the bioavailability and patient compliance.