Effect of aluminium on development of Zebrafish, Brachydanio rerio (Ham.)

Abstract

The Zebrafish (Brachydanio rerio) has been extensively studied and well described for environmental toxicity studies. Molecular biology and genetics have recently been used to elucidate the underlying mechanisms of toxicity in zebrafish and to predict effects in mammals. The application of Brachydanio rerio embryo development technique to research on environmental science was summarized in this paper. This testing technique was approved as one of standard methods for chemical toxicity test, by international organizations (OECD,). There are many advantages of this testing, e.g., low cost, easy operation, high sensitivity and multiple sensible endpoints, comparing with other toxicity testing. Also, it was used to judge toxic mechanism of chemicals. The embryo development of zebrafish can be affected obviously by pollution, heavy metal, pesticide, organic reagent and complex chemicals. Among them, aluminium appeared stronger toxicity. The results are consistent with  behavioral mixed pollutant monitoring and  anatomical analyses of zebrafish (Brachydanio rerio) development.