Simultaneous estimation of Cetirizine hydrochloride, Phenylpropanolamine hydrochloride and Paracetamol by RP-HPLC method

Abstract

The combination of Cetirizine hydrochloride, Phenylpropanolamine Hydrochloride and Paracetamol is used in treatment of anti-allergic, over-the count (OTC) drug products as a nasal decongestant to relieve stuffy nose or nasal congestion & antipyretic. Cetirizine hydrochloride, Phenylpropanolamine hydrochloride and Paracetamol are a potential combination for us. The analytical research is carried out on cetirizine hydrochloride i.e. high-performance Liquid chromatographic determination of  cetirizine in human plasma, urine, serum and phenylpropanolamine hydrochloride high-performance liquid chromatographic determination of phenylpropanolamine hydrochloride in tablet, OTC preparations multicomponent formulations and analysis Paracetamol in tablets by HPLC. We study RP-High Performance Liquid Chromatographic method for the analysis of Cetirizine hydrochloride, Phenylpropanolamine hydrochloride and Paracetamol drugs that is a ternary combination which is simple sensitive and new method and not yet reported in the market.