Dengue Virus and its Structure - A Promising Target for Drug Discovery

Abstract

Dengue is the most endemic disease of last decade; this disease is caused by the infection of Dengue Virus (DENV). This virus completes its lifecycle in Aides mosquito and human. There are several vaccines against this virus but they only prevent from disease and reduce the risk of death. DENV have three serotypes all with minor difference in structure. Immunity against one serotype does not impart immunity against all serotypes in case of infection, it may cause disease extremity. Many researchers believe that it is difficult to develop a vaccine against all serotypes because of difference in structure. A potent inhibitor is required for the disease to be treated. In this study we considered its (DENV) structure and mode of infection so that we can develop or search a promising target and compound for treatment of this disease.