D-Pinitol - A Natural Phytomolecule and its Pharmacological effect

Abstract

D-pinitol is a natural compound related to the important family of
inositol. It can be found and isolated from many plants, being the active
component of ayurvedic remedies from Pinaceae, Asteraceae,
Caryophyllaceae, Zygophyllaceous, Cupressaceae, Aristolochiaceae and
Sapindaceae. It firstly synthesised and structure characterized from the
Sugar pine tree]. D-pinitol is the D-enantiomer of pinitol, it’s a 3-Omethyl-D-chiro-inositol. Fortunately, the pharmacological interest in this
compound has risen various established multifunctional properties
through a variety of signalling pathways: i) anti-cancer, through
inhibition of TNF-ᾳ and suppression of NF-ⱪB pathway; ii)
insulinomimetic and metabolic regulator in type 2 diabetes mellitus, via a
post-receptor pathway of insulin action;
iii) antioxidant; iv) hepatoprotective; v) immuno-modulator, balancing Th1/Th2 cytokines; vi)
osteoporosis preventive, through p38/JNK and NF-ⱪB pathways; vii) anti-aging, via reduction of the
insulin/IGF-1 signalling (IIS) pathway; viii) improver of creatine retention; ix) preventive and
ameliorative of Alzheimer’s disease through selective γ-secretase modulation. Thus, the present review
compresses the literature reported to date in relation to the Pharmacological effects and metabolic
pathways of this naturally occurring compound D- Pinitol ingredient providing an extensive guide for a
future utilization of all of its potentialities. The result came out from the compilation of data brings up
with the conclusion i.e. the d-pinitol is the immerging phytomolecule which possess various
pharmacological activity and therapeutic potency toward various diseases which makes this molecule as a
choice of drug in future for the control of various enlisted disease.