Development and Evaluation of Ethosomal Cream of Luliconazole

Abstract

Luliconazole is used for the treatment of local and systemic fungal infection. But one of the major problems for efficient drug delivery is low penetration rate of luliconazole due to its high solubility and low permeability. Further, the physicochemical modification in the drug by means of phospholipid membrane also promises to prolong the drug action. A number of problems associated with drug molecule such as bioavailability, degradation, stability and side effects can be overcome by incorporating it into ethosomes. In the present work, ethosomal formulation to enhance transdermal permeation of luliconazole was prepared and evaluated using different concentration and optimized formulation was evaluated. Colloidal suspensions of ethosomes were prepared by cold method. Ethosomal system was found to be easy to prepare and composed mainly of phospholipids and ethanol, compounds commonly found in pharmaceutical preparations. The present investigation was to design the ethosomal cream containing luliconazole using different concentration of ethanol and phospholipid. The smooth surface of vesicles and surface was confirmed by the images of ethosomes. The SEM and TEM mage was given in respectively. The entrapment efficiency of ethosome was determined.