Enhancement of Glimepiride dissolution profile by Solid dispersion method

Abstract

The drugs can provide relief,type-II diabetes are poorly soluble in nature. So,formulating them is a tedious and difficult task. So, before formulation their solubilityshouldbeenhancedinordertoincreasedrugavailabilityandbioavailabilitysimultaneously.The main aim of this study solid dispersion with polymerhavinghigh Tgvalue(PVPK30)by solventevaporationtechniquehavingbothadvantage,generationofamorphoussystemandformationofsoliddispersionsimultaneously.This activated system prepared with PVP K 30 as carrier, was able toremarkablyincreasethedissolutionprofileandsolubilityofthepoorlysolubleGlimepiridascomparedtoothersoliddispersiontechniques.alltheratiosofsoliddispersions were dissolved completely within 20minute, and when observed visually,they were found to be dissolved only within 2 minute. While, on the other hand, noneof the physical mixture andpure drugwere dissolvedcompletely even after60minutes.