Formulation and Evaluation of Niosomes of Leonotis nepetaefolia (L.) R.Br.

Abstract

Herbal drug loaded delivery strategies are combined with current scientific technologies, which enhance the therapeutic value of the pharmaceuticals. The objective of this research is to formulate and evaluate Leonotis nepetaefolia (L.) R.Br. hydroalcoholic extract-based niosomal drug delivery system. Analysis of the niosomal dispersion was conducted using particle size entrapment efficiency and in-vitro drug release study. Drug delivery through niosomal formulations is gaining success rapidly at the present time and it could be a suitable carrier for Leonotis nepetaefolia (L.) R.Br. hydroalcoholic extract for the treatment of fungal infection. The results indicates that most promising formulation was NFLN8, which contained Tween 40 as surfactant at ratio of 2:1 with cholesterol.