Formulation Development and Evaluation of Floating Microsphere of Trazodone hydrochloride

Abstract

Floating microspheres of trazodone hydrochloride were prepared by a solvent diffusion- evaporation method. The nature of polymer influenced the physical characteristics as well as floating behaviour of the microspheres. In vitro buoyancy studies confirmed the excellent floating properties. Floating microspheres of trazodone hydrochloride as gastro retentive dosage forms precisely control the release rate of target drug to a specific site and facilitate an enormous impact on health care. These systems also provide tremendous opportunities in the designing of new controlled and delayed release oral formulations, thus extending the frontier of futuristic pharmaceutical development. Furthermore, recent innovations in pharmaceutical investigation will surely provide real prospects for establishment of novel and effective means in the development of these promising drug delivery systems.