Formulation and evaluation of sustained released niosomes containing pregabalin

Abstract

The main objective of the present study was to encapsulate Pregabalin in niosomes for achieving prolonged release & longer duration of action.  Niosomes containing Pregabalin was formulated using two surfactants such as span 40 & span 60 and evaluated for various parameters. The microscopic examination of the prepared niosomes revealed spherical small unilamellar vesicles of 80-120 nm and 250- 280 nm for F I and F II. Invitro release studies showed that the percentage amount of free drug released was 99.04% within 2.5 hours. FI showed 84.99 % of drug release within 19 hours. F II showed 93.48 % of drug release within 20 hours. Storage under refrigerated condition showed greater stability with 97.23% of drug content at the end of 3 months.