Co-crystalization of aceclofenac and paracetamol and their characterization

Abstract

The increase in the aqueous solubility and physicochemical property of insoluble and slightly soluble drugs is of major concern in pharmaceutical formulations. It is commonly recognized in the pharmaceutical industry that on average more than 40% of newly discovered drug candidates are poorly water-soluble. Poor “drug like” properties of lead compounds led to ineffective absorption from the site of administration, which has been designated as an important part of the high clinical failure due to poor pharmacokinetics. In the present work, aceclofenac, a non steroidal anti-inflammatory agent of phenyl acetic acid group, which possesses remarkable antiinflammatory, analgesic and antipyretic properties is selected as a model drug which is BCS class II drug (highly permeable and low soluble). Aceclofenac exhibits slight solubility in water and as a consequence it exhibits low bioavailability after oral administration.