A Method to Enhance Solubility and Tableting Properties by Particle Size Enlargement-Crystallo-Co-Agglomeration

Abstract

Crystallo-co-agglomeration is a novel particle design technique, to
overcome the limitations of spherical crystallization. The process of
Crystallo-co-agglomeration involves crystallization followed by
simultaneous agglomeration of the drug with the aid of either a good
solvent or a bridging liquid and a bad solvent. The agglomeration is
performed using bridging liquid. In the field of powder technology
various attempts has been made to design primary and secondary
particles of pharmaceutical substances for various applications, such as
improvement in solubility of drugs, obtaining suitable polymorph,
improvement in micromeritics and compression properties, and
modification of bioavailability.