Preparation and characterisation of B cyclodextrin aspirin inclusion complex

Abstract

Complexation is the association between two or more molecules to form a noncovalent based complex that has higher solubility than the drug itself. From solubility standpoint, complex can be put in to two categories, stacking complexes and inclusion complexes. The aim of this work was to study the influence of β-cyclodextrin (β-CD) on the biopharmaceutical properties of aspirin. To this purpose the physicochemical characterization of aspirin-β-cyclodextrin binary systems was performed both in solution and solid state. Present study includes deals with the preparation of inclusion complex of Aspirin ß-cyclodextrin as carrier and to evaluate Aspirin ß-cyclodextrin inclusion complex for various parameters viz., % practical yield, drug content, in vitro release study, drug-excipients interaction study, etc.