Skeletal muscle relaxant activity of methanolic extract of Parthenium hysterophorus L. leaves in swiss albino mice

Abstract

The objective of the present study was to evaluate the skeletal muscle relaxant activity of methanolic extract of the leaves of Parthenium hysterophorus L (MEPH) using Rota-Rod method and traction test . MEPH was administered orally at dose of 3mg/kg and 6 mg/kg p.o to Swiss Albino mice. The methanolic extract significantly reduces the fall off time (motor coordination), and highly significant (**P<0.01) at 30 min of duration. It also shows significant muscle relaxant effect in traction test.  Thus, the result suggested that the MEPH possess skeletal muscle relaxantactivity may be due to presence of different chemical compounds present in the extract.