Evaluation of Anti-depressant activity of Centratherum anthelminticum Seeds

Abstract

The antidepressant activity of methanolic extract of Kalijiri (Centratherum anthelminticum) seeds was studied. Kalijiri seeds extracts were obtained by soxhlet extraction method solvent using solvents methanol. The methanolic extract of C. anthelminticum was used for antidepressant activity by forced swim test and tail suspension test. The results showed that mehtanolic extract of CA has good antidepressant activity with 200 mg/kg dose of seed extract respectively with compare to standard (Imipramine). C. anthelminticum contains Flavonoids and terpenoids which are responsible for its antidepressant action. This evidence supports the antidepressant activity of C. anthelminticum.