Formulation and Evaluation of Gokshuradi Churna for the treatment of Pyelonephritis Infection

Abstract

Pyelonephritis, a severe urinary tract infection primarily affecting the kidneys, is commonly caused by uropathogens such as Escherichia coli and Klebsiella pneumoniae. Rising antibiotic resistance has driven interest in alternative therapies, particularly traditional herbal formulations. This study focuses on the formulation and evaluation of Gokshuradi Churna, a classical Ayurvedic polyherbal powder, traditionally used for urinary and renal disorders. The churna was prepared using authenticated herbs including Tribulus terrestris, Asparagus racemosus, Hemidesmus indicus, and Abutilon indicum. The formulation underwent organoleptic, physicochemical, and phytochemical evaluation. Antimicrobial efficacy was assessed using the agar well diffusion method against common pyelonephritis pathogens.

Results indicated significant inhibitory activity, particularly against E. coli, along with acceptable physicochemical properties and the presence of active phytoconstituents such as flavonoids, tannins, and alkaloids. The study concludes that Gokshuradi Churna exhibits promising potential as a natural alternative in managing pyelonephritis infections, warranting further in vivo and clinical investigations.