Anti-ulcer Activity of Ocimum sanctum leaves and Ficus benghalensis Linn. Stem bark Ethanolic Extract in Rats

Abstract

The study aimed to determine whether Ocimum sanctum leaves and Ficus benghalensis Linn stem bark ethanolic extraction might help the rats with gastric ulcers. Given sanctum leaves and Ficus benghalensis Linn stem bark ethanolic extract dose at 250mg/kg, 500mg/kg, & 1000 mg/kg thrice a day for tenure of five days before pyloric ligation ulceration and indomethacin-induced ulceration; anti-ulcer activity was assessed. Several parameters, including "gastric volume, pH of gastric juice, total acidity, ulcer index, and histopathological parameters," were assessed in the controller groups before they received pretreatments of an ethanolic extract of sanctum leaves and Ficus benghalensis stem bark and the commonly used drugs ranitidine. In the indomethacin and pyloric ligation model, pre-treatment with an ethanolic extract of Ocimum sanctum leaves and Ficus benghalensis Linn stem bark and ranitidine significantly decreased the ulcer index and free acidity as compared to the control group. Percentages of ulcer prevention were calculated. The extract improved pH significantly (P0.05) and lowered gastric juice volume, accessibility, and overall acidity. Histopathological findings from albino Wistar rats reveals the ethanolic extraction of sanctum leaves and Ficus benghalensis Linn stem bark had anti-ulcer activities. The ethanolic extract under Ocimum sanctum leaves and Ficus benghalensis Linn stem bark exhibited anti-ulcer activity in two model.