Formulation and Characterization of Phytosomes of Ginger Extract

Abstract

The present study focuses on the Formulation and Characterization of Phytosomes of Ginger Extract with the aim of enhancing its bioavailability and therapeutic efficacy. Ginger (Zingiber officinale) is well known for its potent antioxidant, anti-inflammatory, and gastroprotective properties, primarily attributed to its active constituents such as gingerols and shogaols. However, its clinical application is limited due to poor solubility and low bioavailability. To overcome these challenges, ginger extract was incorporated into phytosomes—a novel drug delivery system that forms a complex between phytoconstituents and phospholipids to improve absorption and stability. The phytosomes were prepared using the solvent evaporation method and were subjected to comprehensive physicochemical characterization including particle size analysis, polydispersity index (PDI), zeta potential, entrapment efficiency, and morphological studies using TEM.

The formulation exhibited nanosized particles with uniform distribution and good stability. The results indicated that phytosomal encapsulation significantly enhanced the solubility and potential for improved bioavailability of ginger phytoconstituents. This study supports the application of phytosome technology as a promising approach for the effective delivery of herbal bioactives like ginger extract.