Study depicting impact of variation of compression speed on Tablet dosage forms formulated with Ibuprofen, Loperamide hydrochloride and Cetirizine dihydrochloride as active ingredients

Abstract

During manufacturing of tablet dosage forms, monitoring of processing
parameters of machines/equipments play an important role in inherent
qualities of manufactured tablets. If these processing parameters are not
controlled as per defined specifications mentioned in batch
manufacturing record of said batch, then it will impact its ideal
characteristics/physical properties as well as its performance and
effectiveness in biological system. Therefore it is very important to
monitor processing parameter like speed of compression machine during
compression stage of tablet manufacturing. In this study, an attempt has
been made to demonstrate impact of variation of processing parameter
(compression machine speed) on ideal properties like weight variation,
hardness, disintegration time and friability of tablet dosage form
manufactured by using active materials of Ibuprofen, Loperamide
Hydrochloride and Cetirizine Dihydrochloride.
In this study individual tablet dosage forms have been formulated by using mentioned active drugs along
with similar excipients. Individual tablets samples were collected after subjecting compression machine to
slow, optimum and fast compression speed for carrying out respective in-process tests of weight variation,
hardness, disintegration time and friability test. Thereafter an comparative analysis have been made
through this study to demonstrate impact of compressing machine speed on ideal characteristics of tablet
dosage forms.