Formulation and Evaluation of in situ topical herbal gel of Flowers of Tecoma stans (L.) Juss. Ex Kunth

Abstract

In the present study, an attempt was made to develop and evaluate topical gel formulations of ethanolic and aqueous flower extract of Tecoma stans (L.) Juss. Ex Kunth having controlled release for direct application in the site of fungal infection. In this study, PLX 407 & 188 has been used as the thermoreversible polymer while HPMC K100M has been used to improve the mucoadhesive and mechanical properties of formulation and to prolong the residence time. TG-1 to TG-6 was formulated using different concentration (0.5, 1.0, 1.5, 2.0, 2.5 & 3.0) of aqueous extract of Tecoma stans (L.) Juss. Ex Kunth, while TG-7 to TG-12 was formulated using different concentration (0.5, 1.0, 1.5, 2.0, 2.5 & 3.0) of ethanolic extract of Tecoma stans (L.) Juss. Ex Kunth. In above mentioned both the extract different proportion (5 to 30 g) of PLX 407 & 188 was added along with three different concentrations (0.25, 0.50 & 0.75) of HPMC K 100 M. The formulated herbal gel was evaluated for various parameters viz., physical appearance, pH, gelling capacity, gelation temperature, viscosity, Syringeability study, Extrudability, Spreadability and drug content.